Mittagsseminar (in cooperation with A. Steger, D. Steurer and B. Sudakov)

Date and Time: Thursday, November 22, 2007, 12:15 pm

Duration: This information is not available in the database

Location: OAT S15/S16/S17

Speaker: Herbert Edelsbrunner (Arts and Sciences Professor of Computer Science and Mathematics, Duke Univ.)

Measuring Periodicity in Gene Expression with Persistence

The work presented in this talk is motivated by microarray experiments aimed at illuminating gene regulation in embryonic somite development. This development is approximately periodic, generating one somite at a time. The microarray experiment yields a one-dimensional function representing expression per gene. We measure the extent to which a function follows the same periodic pattern and is a candidate in participating in the process. To this end we simplify functions, integrate numbers of critical points, and prove the stability of the resulting measure. We evaluate the resulting rankings based on genes for which there is biological evidence of their direct involvement in somite development.

The microarray work is due to Olivier Pourquie and Mary-Lee Dequeant. The assessment of periodicity of the expressions of few thousand gene is done in collaboriation with Yuriy Mileyko.

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