Mittagsseminar (in cooperation with J. Lengler, A. Steger, and D. Steurer)

Date and Time: Tuesday, March 24, 2009, 12:15 pm

Duration: This information is not available in the database

Location: OAT S15/S16/S17

Speaker: Jo Helmuth (Mosaic Group)

Analysis of Spatial Point Patterns in Live Cells

Countless biological and biochemical processes depend on spatial compartmentalization and control of the location of interacting objects. Consequently, the indirect detection of interactions by monitoring locations is of great importance in, e.g., the study of protein interaction networks, transport pathways, or signaling. Fluorescence microscopy is a standard tool to probe the spatial distribution of labeled proteins and other subcellular structures. Apparent spatial colocalization of two classes of objects is often considered strong evidence for mutual interaction or correlated behavior. In this talk, I will focus on the class of colocalization analysis techniques that require reduction of image data to a set of discrete objects. I will present a colocalization measure that is based on the theory of spatial point processes. A natural extension towards interaction measures and links to the Brownian dynamics model of particle motion will be discussed.

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